Почечные транспортеры лекарственных средств: механизмы, клиническое значение и роль в фармакотерапии
Почечные транспортеры (OCT2, MATE1 и MATE2-K) лекарственных средств: механизмы, клиническое значение и роль в фармакотерапии https://dzen.ru/a/aURBiVXTzUKTpAFz 1. Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2 - PMC - NIH, https://pmc.ncbi.nlm.nih.gov/articles/PMC12207590/ 2. Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics - PMC - NIH, https://pmc.ncbi.nlm.nih.gov/articles/PMC3246706/ 3. Clinical Aspects of Drug–Drug Interaction and Drug Nephrotoxicity at Renal Organic Cation Transporters 2 (OCT2) and Multidrug and Toxin Exclusion 1, and 2-K (MATE1/MATE2-K) - J-Stage, https://www.jstage.jst.go.jp/article/bpb/45/4/45_b21-00916/_html/-char/ja 4. Research Methods and New Advances in Drug–Drug Interactions Mediated by Renal Transporters - PMC - NIH, https://pmc.ncbi.nlm.nih.gov/articles/PMC10343503/ 5. OCT2 - Transporters - Solvo Biotechnology, https://www.solvobiotech.com/transporters/oct2 6. (PDF) Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium) - ResearchGate, https://www.researchgate.net/publication/392135028_Predicting_OCT2MATEs-Mediated_Drug_Interactions_in_Healthy_Volunteers_and_Patients_with_Chronic_Kidney_Disease_Insights_from_Extended_Clearance_Concept_Endogenous_Biomarkers_and_In_Vitro_Inhibition_St 7. MATE1 and MATE2K Transporter, https://cdn.fs.pathlms.com/m5oaXU9bR1Sazz3IQgsE?cache=true&dl=true 8. Substrate-specific inhibition of organic cation transporter 1 revealed using a multisubstrate drug cocktail - PMC - NIH, https://pmc.ncbi.nlm.nih.gov/articles/PMC12163485/ 9. MATE1 - Transporters - Solvo Biotechnology, https://www.solvobiotech.com/transporters/mate1 10. MATE2 - Transporters - Solvo Biotechnology, https://www.solvobiotech.com/transporters/mate2 11. Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H+-organic cation antiporters | Request PDF - ResearchGate, https://www.researchgate.net/publication/6322027_Substrate_specificity_of_MATE1_and_MATE2-K_human_multidrug_and_toxin_extrusionsH-organic_cation_antiporters 12. Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2 - PubMed, https://pubmed.ncbi.nlm.nih.gov/40512599/ 13. Quantitative contributions of hepatic and renal organic cation transporters to the clinical pharmacokinetic cimetidine-metformin interaction | bioRxiv, https://www.biorxiv.org/content/10.1101/2024.11.19.624371v1.full-text 14. https://pmc.ncbi.nlm.nih.gov/articles/PMC12598135/ 15. https://www.researchgate.net/publication/256424399_Ondansetron_Can_Enhance_Cisplatin-Induced_Nephrotoxicity_via_Inhibition_of_Multiple_Toxin_and_Extrusion_Proteins_MATEs 16. https://pmc.ncbi.nlm.nih.gov/articles/PMC3830718/ 17. https://pmc.ncbi.nlm.nih.gov/articles/PMC4792735/ 18. https://www.researchgate.net/publication/251233890_Role_of_organic_cation_transporter_OCT2_and_multidrug_and_toxin_extrusion_proteins_MATE1_and_MATE2-K_for_transport_and_drug_interactions_of_the_antiviral_lamivudine 19. SUMMARY OF PRODUCT CHARACTERISTICS - Extranet Systems, https://extranet.who.int/prequal/sites/default/files/whopar_files/HA747%20part4v4_0.pdf 20. https://reference.medscape.com/drug/namzaric-memantine-donepezil-999990 21. https://www.researchgate.net/publication/8496401_Creatinine_Transport_by_Basolateral_Organic_Cation_Transporter_hOCT2_in_the_Human_Kidney 22. Kidney Drug Transporters in Pharmacotherapy - MDPI, https://www.mdpi.com/1422-0067/24/3/2856 23. https://pubs.acs.org/doi/10.1021/acs.jcim.4c00921 24. https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/65eeac0a66c1381729b9206e/original/prediction-of-inhibitory-activity-against-the-mate1-transporter-via-combined-fingerprint-and-physics-based-machine-learning-models.pdf 25. Clinical Aspects of Drug–Drug Interaction and Drug Nephrotoxicity at Renal Organic Cation Transporters 2 (OCT2) and Multidrug and Toxin Exclusion 1, and 2-K (MATE1/MATE2-K) - J-Stage, https://www.jstage.jst.go.jp/article/bpb/45/4/45_b21-00916/_html/-char/en 26. https://hivclinic.ca/wp-content/uploads/2018/11/ARV-and-DAA-pharmacokinetic-characteristics-summary-table.pdf 27. https://escholarship.org/content/qt06q0x5zt/qt06q0x5zt_noSplash_2f87e6f7cb919137798b76837f442241.pdf 28. https://www.fda.gov/drugs/drug-interactions-labeling/healthcare-professionals-fdas-examples-drugs-interact-cyp-enzymes-and-transporter-systems 29. https://www.researchgate.net/publication/392661996_Substrate_Specificity_of_the_Organic_Cation_Transporters_MATE1_and_MATE2K_and_Functional_Overlap_with_OCT1_and_OCT2
Почечные транспортеры (OCT2, MATE1 и MATE2-K) лекарственных средств: механизмы, клиническое значение и роль в фармакотерапии https://dzen.ru/a/aURBiVXTzUKTpAFz 1. Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2 - PMC - NIH, https://pmc.ncbi.nlm.nih.gov/articles/PMC12207590/ 2. Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics - PMC - NIH, https://pmc.ncbi.nlm.nih.gov/articles/PMC3246706/ 3. Clinical Aspects of Drug–Drug Interaction and Drug Nephrotoxicity at Renal Organic Cation Transporters 2 (OCT2) and Multidrug and Toxin Exclusion 1, and 2-K (MATE1/MATE2-K) - J-Stage, https://www.jstage.jst.go.jp/article/bpb/45/4/45_b21-00916/_html/-char/ja 4. Research Methods and New Advances in Drug–Drug Interactions Mediated by Renal Transporters - PMC - NIH, https://pmc.ncbi.nlm.nih.gov/articles/PMC10343503/ 5. OCT2 - Transporters - Solvo Biotechnology, https://www.solvobiotech.com/transporters/oct2 6. (PDF) Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium) - ResearchGate, https://www.researchgate.net/publication/392135028_Predicting_OCT2MATEs-Mediated_Drug_Interactions_in_Healthy_Volunteers_and_Patients_with_Chronic_Kidney_Disease_Insights_from_Extended_Clearance_Concept_Endogenous_Biomarkers_and_In_Vitro_Inhibition_St 7. MATE1 and MATE2K Transporter, https://cdn.fs.pathlms.com/m5oaXU9bR1Sazz3IQgsE?cache=true&dl=true 8. Substrate-specific inhibition of organic cation transporter 1 revealed using a multisubstrate drug cocktail - PMC - NIH, https://pmc.ncbi.nlm.nih.gov/articles/PMC12163485/ 9. MATE1 - Transporters - Solvo Biotechnology, https://www.solvobiotech.com/transporters/mate1 10. MATE2 - Transporters - Solvo Biotechnology, https://www.solvobiotech.com/transporters/mate2 11. Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H+-organic cation antiporters | Request PDF - ResearchGate, https://www.researchgate.net/publication/6322027_Substrate_specificity_of_MATE1_and_MATE2-K_human_multidrug_and_toxin_extrusionsH-organic_cation_antiporters 12. Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2 - PubMed, https://pubmed.ncbi.nlm.nih.gov/40512599/ 13. Quantitative contributions of hepatic and renal organic cation transporters to the clinical pharmacokinetic cimetidine-metformin interaction | bioRxiv, https://www.biorxiv.org/content/10.1101/2024.11.19.624371v1.full-text 14. https://pmc.ncbi.nlm.nih.gov/articles/PMC12598135/ 15. https://www.researchgate.net/publication/256424399_Ondansetron_Can_Enhance_Cisplatin-Induced_Nephrotoxicity_via_Inhibition_of_Multiple_Toxin_and_Extrusion_Proteins_MATEs 16. https://pmc.ncbi.nlm.nih.gov/articles/PMC3830718/ 17. https://pmc.ncbi.nlm.nih.gov/articles/PMC4792735/ 18. https://www.researchgate.net/publication/251233890_Role_of_organic_cation_transporter_OCT2_and_multidrug_and_toxin_extrusion_proteins_MATE1_and_MATE2-K_for_transport_and_drug_interactions_of_the_antiviral_lamivudine 19. SUMMARY OF PRODUCT CHARACTERISTICS - Extranet Systems, https://extranet.who.int/prequal/sites/default/files/whopar_files/HA747%20part4v4_0.pdf 20. https://reference.medscape.com/drug/namzaric-memantine-donepezil-999990 21. https://www.researchgate.net/publication/8496401_Creatinine_Transport_by_Basolateral_Organic_Cation_Transporter_hOCT2_in_the_Human_Kidney 22. Kidney Drug Transporters in Pharmacotherapy - MDPI, https://www.mdpi.com/1422-0067/24/3/2856 23. https://pubs.acs.org/doi/10.1021/acs.jcim.4c00921 24. https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/65eeac0a66c1381729b9206e/original/prediction-of-inhibitory-activity-against-the-mate1-transporter-via-combined-fingerprint-and-physics-based-machine-learning-models.pdf 25. Clinical Aspects of Drug–Drug Interaction and Drug Nephrotoxicity at Renal Organic Cation Transporters 2 (OCT2) and Multidrug and Toxin Exclusion 1, and 2-K (MATE1/MATE2-K) - J-Stage, https://www.jstage.jst.go.jp/article/bpb/45/4/45_b21-00916/_html/-char/en 26. https://hivclinic.ca/wp-content/uploads/2018/11/ARV-and-DAA-pharmacokinetic-characteristics-summary-table.pdf 27. https://escholarship.org/content/qt06q0x5zt/qt06q0x5zt_noSplash_2f87e6f7cb919137798b76837f442241.pdf 28. https://www.fda.gov/drugs/drug-interactions-labeling/healthcare-professionals-fdas-examples-drugs-interact-cyp-enzymes-and-transporter-systems 29. https://www.researchgate.net/publication/392661996_Substrate_Specificity_of_the_Organic_Cation_Transporters_MATE1_and_MATE2K_and_Functional_Overlap_with_OCT1_and_OCT2