A study of causal relationships between human IgG N - glycosylation traits and twelve associated...
A study of causal relationships between human IgG N – glycosylation traits and twelve associated diseases Olga O. Zaytseva, Gordan Lauc, Sodbo Z. Sharapov, Yakov A. Tsepilov, Lucija Klarić N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG Nglycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG Nglycans.
A study of causal relationships between human IgG N – glycosylation traits and twelve associated diseases Olga O. Zaytseva, Gordan Lauc, Sodbo Z. Sharapov, Yakov A. Tsepilov, Lucija Klarić N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG Nglycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG Nglycans.