Ранолазин и Метформин: фармакокинетика через органический катионный транспортер 2 (OCT2)
1. Pharmacokinetic drug-drug interaction study of ranolazine and metformin in subjects with type 2 diabetes mellitus - PubMed, https://pubmed.ncbi.nlm.nih.gov/27128216/ 2. Effect of Ranolazine Monotherapy on Glycemic Control in Subjects With Type 2 Diabetes, https://diabetesjournals.org/care/article/38/7/1189/31053/Effect-of-Ranolazine-Monotherapy-on-Glycemic 3. RANEXA (ranolazine) extended-release tablets - accessdata.fda.gov, https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021526s029lbl.pdf 4. Untitled, https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021526s012lbl.pdf 5. Ranolazine - StatPearls - NCBI Bookshelf, https://www.ncbi.nlm.nih.gov/books/NBK507828/ 6. GLUCOPHAGE® (metformin hydrochloride tablets) - accessdata.fda ..., https://www.accessdata.fda.gov/drugsatfda_docs/label/2000/21202lbl.pdf 7. MetFORMIN Monograph for Professionals - Drugs.com, https://www.drugs.com/monograph/metformin.html 8. This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda, https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/209806s008lbl.pdf 9. 7 Metformin Interactions That Are Best to Avoid - GoodRx, https://www.goodrx.com/metformin/interactions 10. Ranexa - Drug Summary - PDR.Net, https://www.pdr.net/drug-summary/Ranexa-ranolazine-163 11. Attachment: Product Information: Ranolazine - Therapeutic Goods Administration (TGA), https://www.tga.gov.au/sites/default/files/auspar-ranolazine-180220-pi.pdf 12. Influence of OCT2 gene variants on metformin efficacy in type 2 diabetes: insights into pharmacogenomics and drug interactions - PubMed Central, https://pmc.ncbi.nlm.nih.gov/articles/PMC12333187/ 13. Importance of OCT2 and MATE1 for the Cimetidine–Metformin Interaction: Insights from Investigations of Polarized Transport in Single- And Double-Transfected MDCK Cells with a Focus on Perpetrator Disposition | Molecular Pharmaceutics - ACS Publications, https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00416 14. Metformin and ranolazine Interactions - Drugs.com, https://www.drugs.com/drug-interactions/metformin-with-ranolazine-1573-0-1993-0.html?professional=1 15. Pharmacokinetic Drug-Drug Interaction Study of Ranolazine and Metformin in Subjects With Type 2 Diabetes Mellitus | Request PDF - ResearchGate, https://www.researchgate.net/publication/268749857_Pharmacokinetic_Drug-Drug_Interaction_Study_of_Ranolazine_and_Metformin_in_Subjects_With_Type_2_Diabetes_Mellitus 16. Drug Interactions of Metformin Involving Drug Transporter Proteins - PMC - NIH, https://pmc.ncbi.nlm.nih.gov/articles/PMC5788205/ 17. Metformin interactions to avoid - SingleCare, https://www.singlecare.com/blog/metformin-interactions/ 18. Ranolazine: A Contemporary Review | Journal of the American Heart Association, https://www.ahajournals.org/doi/10.1161/jaha.116.003196 19. Ranolazine Extended-Release Tablets - [Product Monograph Template - Standard], https://pdf.hres.ca/dpd_pm/00082255.PDF 20. Effect of Ranolazine on A1C and Glucose Levels in Hyperglycemic Patients With Non-ST Elevation Acute Coronary Syndrome - PubMed Central, https://pmc.ncbi.nlm.nih.gov/articles/PMC2875416/ 21. Blockade of Na+ channels in pancreatic α-cells has antidiabetic effects - PubMed, https://pubmed.ncbi.nlm.nih.gov/24812428/ 22. Untitled, https://pubmed.ncbi.nlm.nih.gov/24812428/#:~:text=Our%20data%20show%20that%20ranolazine,activity%20and%20reduces%20glucagon%20release. 23. Ranolazine recruits muscle microvasculature and enhances insulin action in rats - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC3810821/ 24. Ranolazine Stimulates Glucose Oxidation in Normoxic, Ischemic, and Reperfused Ischemic Rat Hearts | Circulation - American Heart Association Journals, https://www.ahajournals.org/doi/10.1161/01.CIR.93.1.135 25. Effect of ranolazine on glycaemic control in patients with type 2 diabetes treated with either glimepiride or metformin - PubMed, https://pubmed.ncbi.nlm.nih.gov/26749407/ 26. Effect of ranolazine on glycaemic control in patients with type 2 diabetes treated with either glimepiride or metformin - University of Miami, https://scholarship.miami.edu/esploro/outputs/journalArticle/Effect-of-ranolazine-on-glycaemic-control/991031614727902976?institution=01UOML_INST&skipUsageReporting=true&recordUsage=false
1. Pharmacokinetic drug-drug interaction study of ranolazine and metformin in subjects with type 2 diabetes mellitus - PubMed, https://pubmed.ncbi.nlm.nih.gov/27128216/ 2. Effect of Ranolazine Monotherapy on Glycemic Control in Subjects With Type 2 Diabetes, https://diabetesjournals.org/care/article/38/7/1189/31053/Effect-of-Ranolazine-Monotherapy-on-Glycemic 3. RANEXA (ranolazine) extended-release tablets - accessdata.fda.gov, https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021526s029lbl.pdf 4. Untitled, https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021526s012lbl.pdf 5. Ranolazine - StatPearls - NCBI Bookshelf, https://www.ncbi.nlm.nih.gov/books/NBK507828/ 6. GLUCOPHAGE® (metformin hydrochloride tablets) - accessdata.fda ..., https://www.accessdata.fda.gov/drugsatfda_docs/label/2000/21202lbl.pdf 7. MetFORMIN Monograph for Professionals - Drugs.com, https://www.drugs.com/monograph/metformin.html 8. This label may not be the latest approved by FDA. For current labeling information, please visit https://www.fda.gov/drugsatfda, https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/209806s008lbl.pdf 9. 7 Metformin Interactions That Are Best to Avoid - GoodRx, https://www.goodrx.com/metformin/interactions 10. Ranexa - Drug Summary - PDR.Net, https://www.pdr.net/drug-summary/Ranexa-ranolazine-163 11. Attachment: Product Information: Ranolazine - Therapeutic Goods Administration (TGA), https://www.tga.gov.au/sites/default/files/auspar-ranolazine-180220-pi.pdf 12. Influence of OCT2 gene variants on metformin efficacy in type 2 diabetes: insights into pharmacogenomics and drug interactions - PubMed Central, https://pmc.ncbi.nlm.nih.gov/articles/PMC12333187/ 13. Importance of OCT2 and MATE1 for the Cimetidine–Metformin Interaction: Insights from Investigations of Polarized Transport in Single- And Double-Transfected MDCK Cells with a Focus on Perpetrator Disposition | Molecular Pharmaceutics - ACS Publications, https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00416 14. Metformin and ranolazine Interactions - Drugs.com, https://www.drugs.com/drug-interactions/metformin-with-ranolazine-1573-0-1993-0.html?professional=1 15. Pharmacokinetic Drug-Drug Interaction Study of Ranolazine and Metformin in Subjects With Type 2 Diabetes Mellitus | Request PDF - ResearchGate, https://www.researchgate.net/publication/268749857_Pharmacokinetic_Drug-Drug_Interaction_Study_of_Ranolazine_and_Metformin_in_Subjects_With_Type_2_Diabetes_Mellitus 16. Drug Interactions of Metformin Involving Drug Transporter Proteins - PMC - NIH, https://pmc.ncbi.nlm.nih.gov/articles/PMC5788205/ 17. Metformin interactions to avoid - SingleCare, https://www.singlecare.com/blog/metformin-interactions/ 18. Ranolazine: A Contemporary Review | Journal of the American Heart Association, https://www.ahajournals.org/doi/10.1161/jaha.116.003196 19. Ranolazine Extended-Release Tablets - [Product Monograph Template - Standard], https://pdf.hres.ca/dpd_pm/00082255.PDF 20. Effect of Ranolazine on A1C and Glucose Levels in Hyperglycemic Patients With Non-ST Elevation Acute Coronary Syndrome - PubMed Central, https://pmc.ncbi.nlm.nih.gov/articles/PMC2875416/ 21. Blockade of Na+ channels in pancreatic α-cells has antidiabetic effects - PubMed, https://pubmed.ncbi.nlm.nih.gov/24812428/ 22. Untitled, https://pubmed.ncbi.nlm.nih.gov/24812428/#:~:text=Our%20data%20show%20that%20ranolazine,activity%20and%20reduces%20glucagon%20release. 23. Ranolazine recruits muscle microvasculature and enhances insulin action in rats - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC3810821/ 24. Ranolazine Stimulates Glucose Oxidation in Normoxic, Ischemic, and Reperfused Ischemic Rat Hearts | Circulation - American Heart Association Journals, https://www.ahajournals.org/doi/10.1161/01.CIR.93.1.135 25. Effect of ranolazine on glycaemic control in patients with type 2 diabetes treated with either glimepiride or metformin - PubMed, https://pubmed.ncbi.nlm.nih.gov/26749407/ 26. Effect of ranolazine on glycaemic control in patients with type 2 diabetes treated with either glimepiride or metformin - University of Miami, https://scholarship.miami.edu/esploro/outputs/journalArticle/Effect-of-ranolazine-on-glycaemic-control/991031614727902976?institution=01UOML_INST&skipUsageReporting=true&recordUsage=false